My Spec Case has seen a lot of use....and a lot of dirt. Then it got a soaking in "the great handbag disaster of '09" (long story, involving my handbag and everything in it getting soaked). I had nothing to lose by throwing it in the washing machine.
I gained a clean spec case.... and also gained the confidence to say "You can just throw them in the washing machine!" when people ask me about cleaning the framed purses. (I also washed a 90mm coin purse and a zip purse - they were fine, too).
It certainly handled the new whizz-bang front-loader better than the knit top I made for myself last year....